WNK3 kinase is a positive regulator of NKCC2 and NCC, renal cation-Cl(-) cotransporters required for normal blood pressure homeostasis

WNK1 and WNK4 [WNK, with no lysine (K)] are serine-threonine kinases that function as molecular switches, eliciting coordinated effects on diverse ion transport pathways to maintain homeostasis during physiological perturbation. Gain-of-function mutations in either of these genes cause an inherited...

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Autori principali: Rinehart, Jesse, Kahle, Kristopher T., de los Heros, Paola, Vazquez, Norma, Meade, Patricia, Wilson, Frederick H., Hebert, Steven C., Gimenez, Ignacio, Gamba, Gerardo, Lifton, Richard P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2005
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1283841/
https://ncbi.nlm.nih.gov/pubmed/16275913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0508303102
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