Genetic reduction of embryonic leukemia-inhibitory factor production rescues placentation in SOCS3-null embryos but does not prevent inflammatory disease

The suppressor of cytokine-signaling (SOCS) proteins act as negative-feedback inhibitors of cytokine and growth-factor-induced signal transduction. In vivo studies have implicated SOCS3 as a negative regulator of signaling downstream of gp130, the receptor subunit shared by IL-6-like cytokines. Mice...

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מידע ביבליוגרפי
Main Authors: Robb, Lorraine, Boyle, Kristy, Rakar, Steven, Hartley, Lynne, Lochland, Janelle, Roberts, Andrew W., Alexander, Warren S., Metcalf, Donald
פורמט: Artigo
שפה:Inglês
יצא לאור: National Academy of Sciences 2005
נושאים:
Biological Sciences
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC1283454/
https://ncbi.nlm.nih.gov/pubmed/16258063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0508023102
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