Enhanced Immunogenicity of Pneumococcal Surface Adhesin A by Genetic Fusion to Cytokines and Evaluation of Protective Immunity in Mice

Immunization of mice with pneumococcal surface adhesin A (PsaA) emulsified in complete Freund's adjuvant (CFA) provides protection against systemic infection with Streptococcus pneumoniae. Because the use of CFA is not acceptable in humans, we sought to develop alternative means of enhancing th...

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Autores principales: Gor, Dennis O., Ding, Xuedong, Li, Qing, Schreiber, John R., Dubinsky, Michael, Greenspan, Neil S.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2002
Materias:
Microbial Immunity and Vaccines
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC128336/
https://ncbi.nlm.nih.gov/pubmed/12228286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.70.10.5589-5595.2002
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