Enhanced Immunogenicity of Pneumococcal Surface Adhesin A by Genetic Fusion to Cytokines and Evaluation of Protective Immunity in Mice

Immunization of mice with pneumococcal surface adhesin A (PsaA) emulsified in complete Freund's adjuvant (CFA) provides protection against systemic infection with Streptococcus pneumoniae. Because the use of CFA is not acceptable in humans, we sought to develop alternative means of enhancing th...

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Bibliographic Details
Main Authors: Gor, Dennis O., Ding, Xuedong, Li, Qing, Schreiber, John R., Dubinsky, Michael, Greenspan, Neil S.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2002
Subjects:
Microbial Immunity and Vaccines
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC128336/
https://ncbi.nlm.nih.gov/pubmed/12228286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.70.10.5589-5595.2002
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