LEW.1WR1 RATS DEVELOP AUTOIMMUNE DIABETES SPONTANEOUSLY AND IN RESPONSE TO ENVIRONMENTAL PERTURBATION

We describe a new rat model of autoimmune diabetes that arose in a major histocompatibility complex (MHC) congenic LEW rat. Spontaneous diabetes in LEW.1WR1 rats (RT1(u/u/a)) occurs with a cumulative frequency of ∼2% at a median age of 59 days. The disease is characterized by hyperglycemia, glycosur...

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Main Authors: Mordes, John P., Guberski, Dennis L., Leif, Jean H., Woda, Bruce A., Flanagan, Joan F., Greiner, Dale L., Kislauskis, Edward H., Tirabassi, Rebecca S.
Format: Artigo
Jezik:Inglês
Izdano: 2005
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1283095/
https://ncbi.nlm.nih.gov/pubmed/16123363
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