Bovine CD18 Is Necessary and Sufficient To Mediate Mannheimia (Pasteurella) haemolytica Leukotoxin-Induced Cytolysis

Leukotoxin (Lkt) secreted by Mannheimia (Pasteurella) haemolytica is an RTX toxin which is specific for ruminant leukocytes. Lkt binds to β(2) integrins on the surface of bovine leukocytes. β(2) integrins have a common β subunit, CD18, that associates with three distinct α chains, CD11a, CD11b, and...

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Библиографические подробности

Опубликовано в::	Infect Immun
Главные авторы:	Deshpande, M. S., Ambagala, T. C., Ambagala, A. P. N., Kehrli, M. E., Srikumaran, S.
Формат:	Artigo
Язык:	Inglês
Опубликовано:	American Society for Microbiology (ASM) 2002
Предметы:	Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Online-ссылка:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC128227/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12183553/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/IAI.70.9.5058-5068.2002
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