Bovine CD18 Is Necessary and Sufficient To Mediate Mannheimia (Pasteurella) haemolytica Leukotoxin-Induced Cytolysis

Leukotoxin (Lkt) secreted by Mannheimia (Pasteurella) haemolytica is an RTX toxin which is specific for ruminant leukocytes. Lkt binds to β(2) integrins on the surface of bovine leukocytes. β(2) integrins have a common β subunit, CD18, that associates with three distinct α chains, CD11a, CD11b, and...

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izdano v:	Infect Immun
Principais autores:	Deshpande, M. S., Ambagala, T. C., Ambagala, A. P. N., Kehrli, M. E., Srikumaran, S.
Format:	Artigo
Jezik:	Inglês
Izdano:	American Society for Microbiology (ASM) 2002
Teme:	Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Online dostop:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC128227/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12183553/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/IAI.70.9.5058-5068.2002
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