Bovine CD18 Is Necessary and Sufficient To Mediate Mannheimia (Pasteurella) haemolytica Leukotoxin-Induced Cytolysis

Leukotoxin (Lkt) secreted by Mannheimia (Pasteurella) haemolytica is an RTX toxin which is specific for ruminant leukocytes. Lkt binds to β(2) integrins on the surface of bovine leukocytes. β(2) integrins have a common β subunit, CD18, that associates with three distinct α chains, CD11a, CD11b, and...

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Detalhes bibliográficos

Publicado no:	Infect Immun
Principais autores:	Deshpande, M. S., Ambagala, T. C., Ambagala, A. P. N., Kehrli, M. E., Srikumaran, S.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 2002
Assuntos:	Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC128227/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12183553/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/IAI.70.9.5058-5068.2002
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