Bovine CD18 Is Necessary and Sufficient To Mediate Mannheimia (Pasteurella) haemolytica Leukotoxin-Induced Cytolysis

Leukotoxin (Lkt) secreted by Mannheimia (Pasteurella) haemolytica is an RTX toxin which is specific for ruminant leukocytes. Lkt binds to β(2) integrins on the surface of bovine leukocytes. β(2) integrins have a common β subunit, CD18, that associates with three distinct α chains, CD11a, CD11b, and...

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Εκδόθηκε σε:	Infect Immun
Κύριοι συγγραφείς:	Deshpande, M. S., Ambagala, T. C., Ambagala, A. P. N., Kehrli, M. E., Srikumaran, S.
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	American Society for Microbiology (ASM) 2002
Θέματα:	Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Διαθέσιμο Online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC128227/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12183553/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/IAI.70.9.5058-5068.2002
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