Complete rescue of obesity, diabetes, and infertility in db/db mice by neuron-specific LEPR-B transgenes

We have generated mice that carry a neuron-specific leptin receptor (LEPR) transgene whose expression is driven by the rat synapsin I promoter synapsin–LEPR B (SYN-LEPR-B). We have also generated mice that are compound hemizygotes for the transgenes SYN-LEPR-B and neuron-specific enolase–LEPR B (NSE...

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Detalhes bibliográficos
Main Authors: de Luca, Carl, Kowalski, Timothy J., Zhang, Yiying, Elmquist, Joel K., Lee, Charlotte, Kilimann, Manfred W., Ludwig, Thomas, Liu, Shun-Mei, Chua, Streamson C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2005
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1280964/
https://ncbi.nlm.nih.gov/pubmed/16284652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI24059
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