Lepr(db/db) Mice with Senescence Marker Protein-30 Knockout (Lepr(db/db)Smp30(Y/−)) Exhibit Increases in Small Dense-LDL and Severe Fatty Liver Despite Being Fed a Standard Diet

BACKGROUND/AIMS: The senescence marker protein-30 (SMP30) is a 34 kDa protein originally identified in rat liver that shows decreased levels with age. Several functional studies using SMP30 knockout (Smp30(Y/−)) mice established that SMP30 functions as an antioxidant and protects against apoptosis....

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Detalhes bibliográficos
Main Authors: Kondo, Yoshitaka, Hasegawa, Goji, Okada, Hiroshi, Senmaru, Takafumi, Fukui, Michiaki, Nakamura, Naoto, Sawada, Morio, Kitawaki, Jo, Okanoue, Takeshi, Kishimoto, Yuki, Amano, Akiko, Maruyama, Naoki, Obayashi, Hiroshi, Ishigami, Akihito
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3670834/
https://ncbi.nlm.nih.gov/pubmed/23755269
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0065698
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