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Rational Attenuation of a Morbillivirus by Modulating the Activity of the RNA-Dependent RNA Polymerase
Negative-strand RNA viruses encode a single RNA-dependent RNA polymerase (RdRp) which transcribes and replicates the genome. The open reading frame encoding the RdRp from a virulent wild-type strain of rinderpest virus (RPV) was inserted into an expression plasmid. Sequences encoding enhanced green...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology
2005
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1280234/ https://ncbi.nlm.nih.gov/pubmed/16254367 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.22.14330-14338.2005 |
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