Rational Attenuation of a Morbillivirus by Modulating the Activity of the RNA-Dependent RNA Polymerase

Negative-strand RNA viruses encode a single RNA-dependent RNA polymerase (RdRp) which transcribes and replicates the genome. The open reading frame encoding the RdRp from a virulent wild-type strain of rinderpest virus (RPV) was inserted into an expression plasmid. Sequences encoding enhanced green...

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Détails bibliographiques
Auteurs principaux: Brown, David D., Rima, Bertus K., Allen, Ingrid V., Baron, Michael D., Banyard, Ashley C., Barrett, Thomas, Duprex, W. Paul
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2005
Sujets:
Genome Replication and Regulation of Viral Gene Expression
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1280234/
https://ncbi.nlm.nih.gov/pubmed/16254367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.22.14330-14338.2005
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