Mutation of a Single Conserved Nucleotide between the Cloverleaf and Internal Ribosome Entry Site Attenuates Poliovirus Neurovirulence

The chemical synthesis of poliovirus (PV) cDNA combined with the cell-free synthesis of infectious particles yielded virus whose mouse neurovirulence was highly attenuated (J. Cello, A. V. Paul, and E. Wimmer, Science 297:1016-1018, 2002). Compared to the wild-type PV1 (Mahoney) [PV1(M)] sequence, t...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: De Jesus, Nidia, Franco, David, Paul, Aniko, Wimmer, Eckard, Cello, Jeronimo
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1280220/
https://ncbi.nlm.nih.gov/pubmed/16254358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.22.14235-14243.2005
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados