The Dot/Icm Type IV Secretion System of Legionella pneumophila Is Essential for the Induction of Apoptosis in Human Macrophages

We have previously shown that Legionella pneumophila induces caspase 3-dependent apoptosis in mammalian cells during early stages of infection. In this report, we show that nine L. pneumophila strains with mutations in the dotA, dotDCB, icmT, icmGCD, and icmJB loci are completely defective in the in...

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Bibliografische Detailangaben

Veröffentlicht in:	Infect Immun
Hauptverfasser:	Zink, Steven D., Pedersen, Lisa, Cianciotto, Nicholas P., Abu Kwaik, Yousef
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 2002
Schlagworte:	Molecular Pathogenesis
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC127815/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11854262/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/IAI.70.3.1657-1663.2002
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