The Dot/Icm Type IV Secretion System of Legionella pneumophila Is Essential for the Induction of Apoptosis in Human Macrophages

We have previously shown that Legionella pneumophila induces caspase 3-dependent apoptosis in mammalian cells during early stages of infection. In this report, we show that nine L. pneumophila strains with mutations in the dotA, dotDCB, icmT, icmGCD, and icmJB loci are completely defective in the in...

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Detalles Bibliográficos

Publicado en:	Infect Immun
Autores principales:	Zink, Steven D., Pedersen, Lisa, Cianciotto, Nicholas P., Abu Kwaik, Yousef
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	American Society for Microbiology (ASM) 2002
Materias:	Molecular Pathogenesis
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC127815/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11854262/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/IAI.70.3.1657-1663.2002
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