The Dot/Icm Type IV Secretion System of Legionella pneumophila Is Essential for the Induction of Apoptosis in Human Macrophages

We have previously shown that Legionella pneumophila induces caspase 3-dependent apoptosis in mammalian cells during early stages of infection. In this report, we show that nine L. pneumophila strains with mutations in the dotA, dotDCB, icmT, icmGCD, and icmJB loci are completely defective in the in...

Täydet tiedot

Bibliografiset tiedot

Julkaisussa:	Infect Immun
Päätekijät:	Zink, Steven D., Pedersen, Lisa, Cianciotto, Nicholas P., Abu Kwaik, Yousef
Aineistotyyppi:	Artigo
Kieli:	Inglês
Julkaistu:	American Society for Microbiology (ASM) 2002
Aiheet:	Molecular Pathogenesis
Linkit:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC127815/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11854262/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/IAI.70.3.1657-1663.2002
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