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Kinetic probes for inter-domain co-operation in human somatic angiotensin-converting enzyme

s-ACE (the somatic form of angiotensin-converting enzyme) consists of two homologous domains (N- and C-domains), each bearing a catalytic site. Negative co-operativity between the two domains has been demonstrated for cow and pig ACEs. However, for the human enzyme there are conflicting reports in t...

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Autori principali: Skirgello, Olga E., Binevski, Peter V., Pozdnev, Vladimir F., Kost, Olga A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Portland Press Ltd. 2005
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1276965/
https://ncbi.nlm.nih.gov/pubmed/16033330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20050702
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