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Defective insulin receptor activation and altered lipid rafts in Niemann–Pick type C disease hepatocytes
Niemann–Pick type C (NPC) disease is a neuro-visceral cholesterol storage disorder caused by mutations in the NPC-1 or NPC-2 gene. In the present paper, we studied IR (insulin receptor) activation and the plasma-membrane lipid assembly in primary hepatocytes from control and NPC1–/– mice. We have pr...
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| Auteurs principaux: | , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Portland Press Ltd.
2005
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1276947/ https://ncbi.nlm.nih.gov/pubmed/15943586 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20050460 |
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