Mutations in dopachrome tautomerase (Dct) affect eumelanin/pheomelanin synthesis, but do not affect intracellular trafficking of the mutant protein

Dopachrome tautomerase (Dct) is a type I membrane protein and an important regulatory enzyme that plays a pivotal role in the biosynthesis of melanin and in the rapid metabolism of its toxic intermediates. Dct-mutant melanocytes carrying the slaty or slaty light mutations were derived from the skin...

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Bibliographic Details
Main Authors: Costin, Gertrude-E., Valencia, Julio C., Wakamatsu, Kazumasa, Ito, Shosuke, Solano, Francisco, Milac, Adina L., Vieira, Wilfred D., Yamaguchi, Yuji, Rouzaud, François, Petrescu, Andrei-J., Lamoreux, M. Lynn, Hearing, Vincent J.
Format: Artigo
Language:Inglês
Published: Portland Press Ltd. 2005
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1276922/
https://ncbi.nlm.nih.gov/pubmed/15960609
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20042070
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