Identification of the hydrophobic strand in the A–B loop of leptin as major binding site III: implications for large-scale preparation of potent recombinant human and ovine leptin antagonists

Interaction of leptin with its receptors resembles that of interleukin-6 and granulocyte colony-stimulating factor, which interact with their receptors through binding sites I–III. Site III plays a pivotal role in receptors' dimerization or tetramerization and subsequent activation. Leptin'...

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Hlavní autoři: Niv-Spector, Leonora, Gonen-Berger, Dana, Gourdou, Isabelle, Biener, Eva, Gussakovsky, Eugene E., Benomar, Yackir, Ramanujan, Krishnan V., Taouis, Mohammed, Herman, Brian, Callebaut, Isabelle, Djiane, Jean, Gertler, Arieh
Médium: Artigo
Jazyk:Inglês
Vydáno: Portland Press Ltd. 2005
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1276919/
https://ncbi.nlm.nih.gov/pubmed/15952938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20050457
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