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Loss of c-Cbl RING finger function results in high-intensity TCR signaling and thymic deletion
Signaling from the T-cell receptor (TCR) in thymocytes is negatively regulated by the RING finger-type ubiquitin ligase c-Cbl. To further investigate this regulation, we generated mice with a loss-of-function mutation in the c-Cbl RING finger domain. These mice exhibit complete thymic deletion by yo...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2005
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1276723/ https://ncbi.nlm.nih.gov/pubmed/16211006 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600841 |
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