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Caspase-2 primes cancer cells for TRAIL-mediated apoptosis by processing procaspase-8
Although caspase-2 is believed to be involved in death receptor-mediated apoptosis, the exact function, mode of activation, and regulation of caspase-2 remain unknown. Here we show that protein kinase (PK) CK2 phosphorylates procaspase-2 directly at serine-157. When intracellular PKCK2 activity is l...
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| Hauptverfasser: | , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2005
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1276710/ https://ncbi.nlm.nih.gov/pubmed/16193064 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600827 |
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