Reduced Infectivity of a Leishmania donovani Biopterin Transporter Genetic Mutant and Its Use as an Attenuated Strain for Vaccination

Pterins are essential for the growth of Leishmania species, and recent work has led to the isolation of the biopterin transporter BT1. In this study, we inactivated the Leishmania donovani biopterin transporter BT1 by gene disruption mediated by homologous recombination. No transport of biopterin wa...

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Bibliografiska uppgifter
Huvudupphovsmän: Papadopoulou, Barbara, Roy, Gaétan, Breton, Marie, Kündig, Christoph, Dumas, Carole, Fillion, Isabelle, Singh, Ajay K., Olivier, Martin, Ouellette, Marc
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Microbiology 2002
Ämnen:
Fungal and Parasitic Infections
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC127620/
https://ncbi.nlm.nih.gov/pubmed/11748164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.70.1.62-68.2002
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