Reduced Infectivity of a Leishmania donovani Biopterin Transporter Genetic Mutant and Its Use as an Attenuated Strain for Vaccination

Pterins are essential for the growth of Leishmania species, and recent work has led to the isolation of the biopterin transporter BT1. In this study, we inactivated the Leishmania donovani biopterin transporter BT1 by gene disruption mediated by homologous recombination. No transport of biopterin wa...

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Detalhes bibliográficos
Main Authors: Papadopoulou, Barbara, Roy, Gaétan, Breton, Marie, Kündig, Christoph, Dumas, Carole, Fillion, Isabelle, Singh, Ajay K., Olivier, Martin, Ouellette, Marc
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2002
Assuntos:
Fungal and Parasitic Infections
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC127620/
https://ncbi.nlm.nih.gov/pubmed/11748164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.70.1.62-68.2002
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