ER stress-regulated translation increases tolerance to extreme hypoxia and promotes tumor growth

Tumor cell adaptation to hypoxic stress is an important determinant of malignant progression. While much emphasis has been placed on the role of HIF-1 in this context, the role of additional mechanisms has not been adequately explored. Here we demonstrate that cells cultured under hypoxic/anoxic con...

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Detalhes bibliográficos
Main Authors: Bi, Meixia, Naczki, Christine, Koritzinsky, Marianne, Fels, Diane, Blais, Jaime, Hu, Nianping, Harding, Heather, Novoa, Isabelle, Varia, Mahesh, Raleigh, James, Scheuner, Donalyn, Kaufman, Randal J, Bell, John, Ron, David, Wouters, Bradly G, Koumenis, Constantinos
Formato: Artigo
Idioma:Inglês
Publicado em: 2005
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1276162/
https://ncbi.nlm.nih.gov/pubmed/16148948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600777
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