ER stress-regulated translation increases tolerance to extreme hypoxia and promotes tumor growth

Tumor cell adaptation to hypoxic stress is an important determinant of malignant progression. While much emphasis has been placed on the role of HIF-1 in this context, the role of additional mechanisms has not been adequately explored. Here we demonstrate that cells cultured under hypoxic/anoxic con...

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Détails bibliographiques
Auteurs principaux: Bi, Meixia, Naczki, Christine, Koritzinsky, Marianne, Fels, Diane, Blais, Jaime, Hu, Nianping, Harding, Heather, Novoa, Isabelle, Varia, Mahesh, Raleigh, James, Scheuner, Donalyn, Kaufman, Randal J, Bell, John, Ron, David, Wouters, Bradly G, Koumenis, Constantinos
Format: Artigo
Langue:Inglês
Publié: 2005
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1276162/
https://ncbi.nlm.nih.gov/pubmed/16148948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600777
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