Turn-on switch in parathyroid hormone receptor by a two-step parathyroid hormone binding mechanism

Parathyroid hormone (PTH) and its related receptor (PTHR) are essential regulators of calcium homeostasis and bone physiology. PTH activates PTHR by interacting with a ligand-binding site localized within the N-terminal extracellular domain (the N-domain) and the domain comprising the seven transmem...

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Главные авторы: Castro, Marián, Nikolaev, Viacheslav O., Palm, Dieter, Lohse, Martin J., Vilardaga, Jean-Pierre
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2005
Предметы:
Biological Sciences
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC1276049/
https://ncbi.nlm.nih.gov/pubmed/16236727
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0503942102
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