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Turn-on switch in parathyroid hormone receptor by a two-step parathyroid hormone binding mechanism
Parathyroid hormone (PTH) and its related receptor (PTHR) are essential regulators of calcium homeostasis and bone physiology. PTH activates PTHR by interacting with a ligand-binding site localized within the N-terminal extracellular domain (the N-domain) and the domain comprising the seven transmem...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2005
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1276049/ https://ncbi.nlm.nih.gov/pubmed/16236727 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0503942102 |
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