Inhibition of colony-stimulating-factor-1 signaling in vivo with the orally bioavailable cFMS kinase inhibitor GW2580

Colony-stimulating-factor-1 (CSF-1) signaling through cFMS receptor kinase is increased in several diseases. To help investigate the role of cFMS kinase in disease, we identified GW2580, an orally bioavailable inhibitor of cFMS kinase. GW2580 completely inhibited human cFMS kinase in vitro at 0.06 μ...

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Main Authors: Conway, James G., McDonald, Brad, Parham, Janet, Keith, Barry, Rusnak, David W., Shaw, Eva, Jansen, Marilyn, Lin, Peiyuan, Payne, Alan, Crosby, Renae M., Johnson, Jennifer H., Frick, Lloyd, Lin, Min-Hwa Jasmine, Depee, Scott, Tadepalli, Sarva, Votta, Bart, James, Ian, Fuller, Karen, Chambers, Timothy J., Kull, Frederick C., Chamberlain, Stanley D., Hutchins, Jeff T.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2005
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1276040/
https://ncbi.nlm.nih.gov/pubmed/16249345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0502000102
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