Pharmacological inhibition of CSF1R by GW2580 reduces microglial proliferation and is protective against neuroinflammation and dopaminergic neurodegeneration

Increased pro-inflammatory cytokine levels and proliferation of activated microglia have been found in Parkinson’s disease (PD) patients and animal models of PD, suggesting that targeting of the microglial inflammatory response may result in neuro-protection in PD. Microglial proliferation is regula...

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Detalhes bibliográficos
Publicado no:FASEB J
Main Authors: Neal, Matthew L., Fleming, Sheila M., Budge, Kevin M., Boyle, Alexa M., Kim, Chunki, Alam, Gelareh, Beier, Eric E., Wu, Long-Jun, Richardson, Jason R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7212500/
https://ncbi.nlm.nih.gov/pubmed/31914683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201900567RR
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