In Vivo Activities of Farnesyl Pyrophosphate Synthase Inhibitors against Leishmania donovani and Toxoplasma gondii

The in vivo activities of three bisphosphonates were determined against Leishmania donovani and Toxoplasma gondii. Alendronate was essentially inactive against both parasites. Pamidronate was active against L. donovani by intravenous administration. Risedronate had a 50% effective dosage of five 2.6...

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Detalhes bibliográficos
Main Authors: Yardley, Vanessa, Khan, Anis A., Martin, Michael B., Slifer, Teri R., Araujo, Fausto G., Moreno, Silvia N. J., Docampo, Roberto, Croft, Simon L., Oldfield, Eric
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2002
Assuntos:
Experimental Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC127510/
https://ncbi.nlm.nih.gov/pubmed/11850291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.46.3.929-931.2002
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