In Vivo Activities of Farnesyl Pyrophosphate Synthase Inhibitors against Leishmania donovani and Toxoplasma gondii

The in vivo activities of three bisphosphonates were determined against Leishmania donovani and Toxoplasma gondii. Alendronate was essentially inactive against both parasites. Pamidronate was active against L. donovani by intravenous administration. Risedronate had a 50% effective dosage of five 2.6...

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Pubblicato in:	Antimicrob Agents Chemother
Autori principali:	Yardley, Vanessa, Khan, Anis A., Martin, Michael B., Slifer, Teri R., Araujo, Fausto G., Moreno, Silvia N. J., Docampo, Roberto, Croft, Simon L., Oldfield, Eric
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 2002
Soggetti:	Experimental Therapeutics
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC127510/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11850291/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.46.3.929-931.2002
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