Broad-Spectrum Antiherpes Activities of 4-Hydroxyquinoline Carboxamides, a Novel Class of Herpesvirus Polymerase Inhibitors

Through broad screening of the compound library at Pharmacia, a naphthalene carboxamide was identified as a nonnucleoside inhibitor of human cytomegalovirus (HCMV) polymerase. Structure-activity relationship studies demonstrated that a quinoline ring could be substituted for naphthalene, resulting i...

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Опубліковано в::	Antimicrob Agents Chemother
Автори:	Oien, Nancee L., Brideau, Roger J., Hopkins, Todd A., Wieber, Janet L., Knechtel, Mary L., Shelly, John A., Anstadt, Robert A., Wells, Peter A., Poorman, Roger A., Huang, Audris, Vaillancourt, Vallerie A., Clayton, Terrance L., Tucker, John A., Wathen, Michael W.
Формат:	Artigo
Мова:	Inglês
Опубліковано:	American Society for Microbiology (ASM) 2002
Предмети:	Antiviral Agents
Онлайн доступ:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC127502/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11850254/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.46.3.724-730.2002
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