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Broad-Spectrum Antiherpes Activities of 4-Hydroxyquinoline Carboxamides, a Novel Class of Herpesvirus Polymerase Inhibitors

Through broad screening of the compound library at Pharmacia, a naphthalene carboxamide was identified as a nonnucleoside inhibitor of human cytomegalovirus (HCMV) polymerase. Structure-activity relationship studies demonstrated that a quinoline ring could be substituted for naphthalene, resulting i...

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Publicado no:Antimicrob Agents Chemother
Principais autores: Oien, Nancee L., Brideau, Roger J., Hopkins, Todd A., Wieber, Janet L., Knechtel, Mary L., Shelly, John A., Anstadt, Robert A., Wells, Peter A., Poorman, Roger A., Huang, Audris, Vaillancourt, Vallerie A., Clayton, Terrance L., Tucker, John A., Wathen, Michael W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2002
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC127502/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11850254/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.46.3.724-730.2002
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