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Broad-Spectrum Antiherpes Activities of 4-Hydroxyquinoline Carboxamides, a Novel Class of Herpesvirus Polymerase Inhibitors

Through broad screening of the compound library at Pharmacia, a naphthalene carboxamide was identified as a nonnucleoside inhibitor of human cytomegalovirus (HCMV) polymerase. Structure-activity relationship studies demonstrated that a quinoline ring could be substituted for naphthalene, resulting i...

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Uloženo v:
Vydáno v:Antimicrob Agents Chemother
Hlavní autoři: Oien, Nancee L., Brideau, Roger J., Hopkins, Todd A., Wieber, Janet L., Knechtel, Mary L., Shelly, John A., Anstadt, Robert A., Wells, Peter A., Poorman, Roger A., Huang, Audris, Vaillancourt, Vallerie A., Clayton, Terrance L., Tucker, John A., Wathen, Michael W.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology (ASM) 2002
Témata:
Antiviral Agents
On-line přístup:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC127502/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11850254/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.46.3.724-730.2002
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