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Broad-Spectrum Antiherpes Activities of 4-Hydroxyquinoline Carboxamides, a Novel Class of Herpesvirus Polymerase Inhibitors

Through broad screening of the compound library at Pharmacia, a naphthalene carboxamide was identified as a nonnucleoside inhibitor of human cytomegalovirus (HCMV) polymerase. Structure-activity relationship studies demonstrated that a quinoline ring could be substituted for naphthalene, resulting i...

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Publikašuvnnas:Antimicrob Agents Chemother
Váldodahkkit: Oien, Nancee L., Brideau, Roger J., Hopkins, Todd A., Wieber, Janet L., Knechtel, Mary L., Shelly, John A., Anstadt, Robert A., Wells, Peter A., Poorman, Roger A., Huang, Audris, Vaillancourt, Vallerie A., Clayton, Terrance L., Tucker, John A., Wathen, Michael W.
Materiálatiipa: Artigo
Giella:Inglês
Almmustuhtton: American Society for Microbiology (ASM) 2002
Fáttát:
Antiviral Agents
Liŋkkat:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC127502/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11850254/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.46.3.724-730.2002
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