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Optimal Dose of Amoxicillin in Treatment of Otitis Media Caused by a Penicillin-Resistant Pneumococcus Strain in the Gerbil Model

Amoxicillin at doses of 0.2 to 5 mg/kg of body weight was administered for the treatment of pneumococcal otitis media in a gerbil model. Doses greater than or equal to 2.5 mg/kg, which resulted in concentrations in middle ear fluid of ≥1.4 μg/ml and concentrations in serum higher than the MIC (1 μg/...

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Udgivet i:Antimicrob Agents Chemother
Principais autores: Parra, Araceli, Ponte, Carmen, Cenjor, Carlos, García-Calvo, Gloria, Giménez, María José, Aguilar, Lorenzo, Soriano, Francisco
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2002
Fag:
Experimental Therapeutics
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC127470/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11850273/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.46.3.859-862.2002
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