Interleukin-4 (IL-4) and IL-10 Collude in Vaccine Failure for Novel Exacerbatory Antigens in Murine Leishmania major Infection

Leishmaniasis affects 12 million people but there are no vaccines in routine use. Recently, we used DNA vaccination in a susceptible BALB/c high-dose model of infection to screen 100 novel Leishmania major genes as vaccine candidates. In addition to finding novel protective antigens, we identified s...

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Bibliographic Details
Main Authors: Roberts, Mark T. M., Stober, Carmel B., McKenzie, Andrew N, Blackwell, Jenefer M.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2005
Subjects:
Fungal and Parasitic Infections
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1273906/
https://ncbi.nlm.nih.gov/pubmed/16239566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.73.11.7620-7628.2005
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