DNA-Salmonella enterica Serovar Typhimurium Primer-Booster Vaccination Biases towards T Helper 1 Responses and Enhances Protection against Leishmania major Infection in Mice

Successful resolution of infections by intracellular pathogens requires gamma interferon (IFN-γ). DNA vaccines promote T helper 1 (Th1) responses by triggering interleukin-12 (IL-12) release by dendritic cells (DC) through Toll-like receptor 9 (TLR9). In humans TLR9 is restricted to plasmacytoid DC....

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Detalhes bibliográficos
Main Authors: Lange, Uta G., Mastroeni, Pietro, Blackwell, Jenefer M., Stober, Carmel B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2004
Assuntos:
Fungal and Parasitic Infections
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC470645/
https://ncbi.nlm.nih.gov/pubmed/15271962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.72.8.4924-4928.2004
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