Efficacy of Orally Delivered Cochleates Containing Amphotericin B in a Murine Model of Aspergillosis

Cochleates containing amphotericin B (CAMB) were administered orally at doses ranging from 0 to 40 mg/kg of body weight/day for 14 days in a murine model of systemic aspergillosis. The administration of oral doses of CAMB (20 and 40 mg/kg/day) resulted in a survival rate of 70% and a reduction in co...

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Detalhes bibliográficos
Main Authors: Delmas, G., Park, S., Chen, Z. W., Tan, F., Kashiwazaki, R., Zarif, L., Perlin, D. S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2002
Assuntos:
Experimental Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC127382/
https://ncbi.nlm.nih.gov/pubmed/12121962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.46.8.2704-2707.2002
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