Antibacterial Activities and Characterization of Novel Inhibitors of LpxC

Lipid A is the hydrophobic anchor of lipopolysaccharide (LPS) and forms the major lipid component of the outer monolayer of the outer membrane of gram-negative bacteria. Lipid A is required for bacterial growth and virulence, and inhibition of its biosynthesis is lethal to bacteria. UDP-3-O-(R-3-hyd...

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Bibliografiske detaljer
Main Authors: Clements, John M., Coignard, Fanny, Johnson, Ian, Chandler, Stephen, Palan, Shilpa, Waller, Andrew, Wijkmans, Jac, Hunter, Michael G.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2002
Fag:
Mechanisms of Action: Physiological Effects
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC127247/
https://ncbi.nlm.nih.gov/pubmed/12019092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.46.6.1793-1799.2002
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