Antibacterial Activities and Characterization of Novel Inhibitors of LpxC

Lipid A is the hydrophobic anchor of lipopolysaccharide (LPS) and forms the major lipid component of the outer monolayer of the outer membrane of gram-negative bacteria. Lipid A is required for bacterial growth and virulence, and inhibition of its biosynthesis is lethal to bacteria. UDP-3-O-(R-3-hyd...

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Podrobná bibliografie

Vydáno v:	Antimicrob Agents Chemother
Hlavní autoři:	Clements, John M., Coignard, Fanny, Johnson, Ian, Chandler, Stephen, Palan, Shilpa, Waller, Andrew, Wijkmans, Jac, Hunter, Michael G.
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	American Society for Microbiology (ASM) 2002
Témata:	Mechanisms of Action: Physiological Effects
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC127247/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12019092/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.46.6.1793-1799.2002
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