Synergistic Effect of Ofloxacin and Magnesium Deficiency on Joint Cartilage in Immature Rats

Single high oral doses of fluoroquinolones (e.g., 1,200 mg of ofloxacin/kg of body weight) are chondrotoxic in juvenile rats. Characteristic cartilage lesions are detectable as early as 12 h after treatment. Since this dosing regimen does not reflect the therapeutic situation, we studied the effects...

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Pubblicato in:	Antimicrob Agents Chemother
Autori principali:	Lozo, Edith, Riecke, Kai, Schwabe, Rudolf, Vormann, Jürgen, Stahlmann, Ralf
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 2002
Soggetti:	Pharmacology
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC127237/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12019086/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.46.6.1755-1759.2002
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