Synergistic Effect of Ofloxacin and Magnesium Deficiency on Joint Cartilage in Immature Rats
Single high oral doses of fluoroquinolones (e.g., 1,200 mg of ofloxacin/kg of body weight) are chondrotoxic in juvenile rats. Characteristic cartilage lesions are detectable as early as 12 h after treatment. Since this dosing regimen does not reflect the therapeutic situation, we studied the effects...
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| Publicado no: | Antimicrob Agents Chemother |
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| Principais autores: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology (ASM)
2002
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC127237/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12019086/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.46.6.1755-1759.2002 |
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