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Coupling of caspase-9 to Apaf1 in response to loss of pRb or cytotoxic drugs is cell-type-specific

Inactivation of the tumor suppressor Rb in the mouse induces cell death, which depends entirely (in lens, CNS) and only partly (PNS, skeletal muscles) on Apaf1/Ced4, an apoptosomal factor thought to be required for processing procaspase-9 following mitochondrial permeabilization. Here, we report tha...

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Detalhes bibliográficos
Main Authors: Ho, Andrew T, Li, Qin H, Hakem, Razqallah, Mak, Tak W, Zacksenhaus, Eldad
Formato: Artigo
Idioma:Inglês
Publicado em: 2004
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1271749/
https://ncbi.nlm.nih.gov/pubmed/14713951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600039
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