Pharmacodynamic Assessment of Clarithromycin in a Murine Model of Pneumococcal Pneumonia

The pharmacodynamic profile of clarithromycin (CLR) was evaluated with a murine model of pneumonia. Eight Streptococcus pneumoniae isolates, including three macrolide-sensitive and five macrolide-resistant strains, were inoculated intratracheally into immunocompromised ICR mice as 10(8)-CFU bacteria...

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Pubblicato in:	Antimicrob Agents Chemother
Autori principali:	Tessier, Pamela R., Kim, Myo-Kyoung, Zhou, Wen, Xuan, Dawei, Li, Chonghua, Ye, Min, Nightingale, Charles H., Nicolau, David P.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 2002
Soggetti:	Experimental Therapeutics
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC127127/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11959578/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.46.5.1425-1434.2002
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