Pharmacodynamic Assessment of Clarithromycin in a Murine Model of Pneumococcal Pneumonia

The pharmacodynamic profile of clarithromycin (CLR) was evaluated with a murine model of pneumonia. Eight Streptococcus pneumoniae isolates, including three macrolide-sensitive and five macrolide-resistant strains, were inoculated intratracheally into immunocompromised ICR mice as 10(8)-CFU bacteria...

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Main Authors: Tessier, Pamela R., Kim, Myo-Kyoung, Zhou, Wen, Xuan, Dawei, Li, Chonghua, Ye, Min, Nightingale, Charles H., Nicolau, David P.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2002
Fag:
Experimental Therapeutics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC127127/
https://ncbi.nlm.nih.gov/pubmed/11959578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.46.5.1425-1434.2002
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