Oxazolidinone Antibiotics Target the P Site on Escherichia coli Ribosomes

The oxazolidinones are a novel class of antimicrobial agents that target protein synthesis in a wide spectrum of gram-positive and anaerobic bacteria. The oxazolidinone PNU-100766 (linezolid) inhibits the binding of fMet-tRNA to 70S ribosomes. Mutations to oxazolidinone resistance in Halobacterium h...

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Détails bibliographiques
Auteurs principaux: Aoki, Hiroyuki, Ke, Lizhu, Poppe, Susan M., Poel, Toni J., Weaver, Elizabeth A., Gadwood, Robert C., Thomas, Richard C., Shinabarger, Dean L., Ganoza, M. Clelia
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2002
Sujets:
Mechanisms of Action: Physiological Effects
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC127084/
https://ncbi.nlm.nih.gov/pubmed/11897593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.46.4.1080-1085.2002
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