Very Low Cefotaxime Concentrations Select for Hypermutable Streptococcus pneumoniae Populations

A mixed culture of an hypermutable hexA Streptococcus pneumoniae mutant strain and its hexA(+) isogenic ancestor was challenged with low cefotaxime concentrations. Despite identical original cefotaxime MICs, the hexA mutant population was significantly selected at very low concentrations, and all of...

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Bibliographic Details
Main Authors: Negri, María-Cristina, Morosini, María-Isabel, Baquero, María-Rosario, Campo, Rosa del, Blázquez, Jesús, Baquero, Fernando
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2002
Subjects:
Mechanisms of Resistance
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC127056/
https://ncbi.nlm.nih.gov/pubmed/11796370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.46.2.528-530.2002
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