Very Low Cefotaxime Concentrations Select for Hypermutable Streptococcus pneumoniae Populations

A mixed culture of an hypermutable hexA Streptococcus pneumoniae mutant strain and its hexA(+) isogenic ancestor was challenged with low cefotaxime concentrations. Despite identical original cefotaxime MICs, the hexA mutant population was significantly selected at very low concentrations, and all of...

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Bibliografiske detaljer

Udgivet i:	Antimicrob Agents Chemother
Principais autores:	Negri, María-Cristina, Morosini, María-Isabel, Baquero, María-Rosario, Campo, Rosa del, Blázquez, Jesús, Baquero, Fernando
Format:	Artigo
Sprog:	Inglês
Udgivet:	American Society for Microbiology (ASM) 2002
Fag:	Mechanisms of Resistance
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC127056/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11796370/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.46.2.528-530.2002
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