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Convulsant and Subconvulsant Doses of Norfloxacin in the Presence and Absence of Biphenylacetic Acid Alter Extracellular Hippocampal Glutamate but Not Gamma-Aminobutyric Acid Levels in Conscious Rats

Fluoroquinolones are antibiotics with central excitatory side effects. These adverse effects presumably result from inhibition of γ-aminobutyric acid (GABA) binding to GABA(A) receptors. This GABA antagonistic effect is greatly potentiated by the active metabolite of fenbufen, biphenylacetic acid (B...

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Udgivet i:Antimicrob Agents Chemother
Principais autores: Smolders, I., Gousseau, C., Marchand, S., Couet, W., Ebinger, G., Michotte, Y.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2002
Fag:
Pharmacology
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC127025/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11796360/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.46.2.471-477.2002
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