Haploinsufficiency of Flap endonuclease (Fen1) leads to rapid tumor progression

Flap endonuclease (Fen1) is required for DNA replication and repair, and defects in the gene encoding Fen1 cause increased accumulation of mutations and genome rearrangements. Because mutations in some genes involved in these processes cause cancer predisposition, we investigated the possibility tha...

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מידע ביבליוגרפי
Main Authors: Kucherlapati, Melanie, Yang, Kan, Kuraguchi, Mari, Zhao, Jie, Lia, Maria, Heyer, Joerg, Kane, Michael F., Fan, Kunhua, Russell, Robert, Brown, Anthony M. C., Kneitz, Burkhard, Edelmann, Winfried, Kolodner, Richard D., Lipkin, Martin, Kucherlapati, Raju
פורמט: Artigo
שפה:Inglês
יצא לאור: The National Academy of Sciences 2002
נושאים:
Biological Sciences
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC126601/
https://ncbi.nlm.nih.gov/pubmed/12119409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.152321699
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